Olaparib is also called by its brand name Lynparza. It is a treatment for some people with:

• ovarian cancer

• fallopian tube cancer

• peritoneal cancer

It is for people who have a change in a gene called BRCA.

It is given if your cancer has come back (relapsed) after previously having a type of chemotherapy called platinum chemotherapy.

This medication is also used for people who have responded well to platinum chemotherapy. They receive it as maintenance treatment after chemotherapy.

Dosage forms & Strengths:

tablet or capsule

• 100 mg

• 150 mg

How Does It Work

PARP is short for Poly (ADP-ribose) polymerase. It is a protein that helps damaged cells to repair themselves. Lynparza stops PARP from working.

Some cancer cells rely on PARP to keep their DNA healthy. This includes cancer cells with a change in the BRCA gene. So, when Lynparza stops PARP from repairing DNA damage, the cancer cells die.

This is a type of targeted cancer medication, called a cancer growth blocker.

How Should You Take Lynparza?

Lynparza comes as a tablet or a capsule to take by mouth twice daily with or without food. Try to space your doses about 12 hours apart.

Take Lynparza at around the same times every day. Follow the directions on your prescription label carefully and ask your doctor or pharmacist to explain any part you do not understand.

Take Lynparza exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the tablet or capsule whole; do not crush chew, divide, or dissolve them

What Should I Tell My Healthcare Provider Before Taking Lynparza?

Before taking Lynparza, tell your healthcare provider about all of your medical conditions, including if you:

• have lung or breathing problems

• have kidney problems

• are pregnant, or plan to become pregnant.

• are breastfeeding or plan to breastfeed.

• are taking other medications, including prescription and over-the-counter medications, vitamins, and herbal supplements.

What Other Medications Interact with Lynparza?

Other medications such as itraconazole (SPORANOX®) and rifampicin (RIFADIN®) may interact with Lynparza. Tell your doctor if you are taking these or any other medications as you may need extra blood tests, or your dose may need to be changed. Check with your doctor or pharmacist before you start or stop taking any other medications.

Avoid grapefruit and grapefruit juice for the duration of your treatment, as these may interact with Lynparza.

The drinking of alcohol (in small amounts) does not appear to affect the safety or usefulness of Lynparza.

What are the possible side effects of Lynparza?

Lynparza may cause serious side effects, including:

• Bone marrow problems called myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML).

• Lung problems (pneumonitis)

Here are the most common side effects seen with Lynparza:

• Nausea or vomiting

• Low number of red or white blood cells

• Abdominal (stomach-area) pain

• Dizziness

• Tiredness or weakness

• Sore throat or runny nose

• Diarrhea

• Joint, muscle, and back pain

• Headache

• Constipation

• Mouth sores

• Respiratory tract infections

• Changes in kidney function blood test

• Changes in the way food tastes

• Loss of appetite

• Low number of platelets

• Indigestion or heartburn

These are not all the possible side effects of Lynparza

What Happens If I Overdose?

Seek emergency medical attention or call the Poison Help line

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