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Your order for Vagifem (Estradiol) will be shipped in discreet packaging so whether the item is shipped to your home or work no one will know the contents of the shipment until opened

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Vagifem (Estradiol)


Select product strength:



Estradiol Hemihydrate

Prescription Required

10mcg 18 tab $128.04

Product of Canada - Manufactured by Novo Nordisk

10mcg 36 tab $228.11

Product of Canada - Manufactured by Novo Nordisk

Estradiol Hemihydrate

Prescription Required

10mcg 24 dose $95.50

Product of United Kingdom - Manufactured by Novo Nordisk

10mcg 48 dose $171.00

Product of United Kingdom - Manufactured by Novo Nordisk

Estradiol Hemihydrate

Prescription Required

10mcg 24 tab $83.04

Product of United Kingdom - Manufactured by Various (UK)

10mcg 48 tab $159.84

Product of United Kingdom - Manufactured by Various (UK)

Frequently Purchased Together
Product Information ​

*Product images are for reference only

Other products containing Estrogens:

  1. Estrace
  2. Estring
  3. Femring
  4. Imvexxy 
  5. Ortho Dienestrol
  6. Premarin
  7. Premarin Vaginal Cream
  8. Vagifem

Estradiol is the generic name of Vagifem.

Estradiol is a form of estrogen, a female sex hormone that regulates many processes in the body.

Estradiol Vaginal tablets are used to relieve menopausal symptoms in the vagina such as dryness or irritation. In medical terms this is known as ‘vaginal atrophy’. It is caused by a drop in the levels of estrogen in your body. This happens naturally after the menopause.


Estradiol Vaginal tablets (Vagifem), belongs to a group of medicines called Hormone Replacement Therapy (HRT). It works by supplementing the falling levels of estrogen in the body and thereby helps to reduce the distressing symptoms of the menopause.

Estradiol Vaginal Tablets (Vagifem) may also be used for purposes not listed in this medication guide.

Estradiol Vaginal tablets treat the loss of vaginal estrogen, which is the underlying cause of your symptoms. Even though you may not see results right away, it begins working to help replenish vaginal estrogen when you start using it. Most bothersome vaginal symptoms are reduced between 8 – 12 weeks of treatment.

You should not use estradiol if you are allergic to it, or if you have:

  • unusual vaginal bleeding that has not been checked by a doctor;
  • liver disease;
  • a history of heart attack, stroke, or blood clot in the vein or a blood clot disorder;
  • an increased risk of having blood clots due to a heart problem or a hereditary blood disorder;
  • a history of hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina; or
  • untreated endometrial hyperplasia

Estradiol Vaginal tablet is for use in postmenopausal women only. If you become pregnant, stop using this medication and contact your doctor.

Smoking can greatly increase your risk of blood clots, stroke, or heart attack while using estradiol. This should be avoided.

Use of other vaginal products should be avoided without your doctor’s advice.

Grapefruit and its products may interact with estradiol and lead to unwanted side effects.  Avoid Grapefruit.

Tell your doctor if you have ever had or may be:

  • heart disease;
  • liver problems, or jaundice caused by pregnancy or taking hormones;
  • kidney disease;
  • gall bladder disease;
  • asthma;
  • epilepsy or other seizure disorder;
  • migraines;
  • lupus;
  • endometriosis or uterine fibroid tumors;
  • hereditary angioedema;
  • porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system);
  • a thyroid disorder;
  • high or low levels of calcium in your blood; or
  • pregnant or breastfeeding

Please tell your doctor or pharmacist if you are using or have recently used any other medicines, including medicines obtained without a prescription, herbal medicines or other natural products.

However, Estradiol Vaginal Tablets (Vagifem) is used for a local treatment in the vagina and is not likely to affect other medicines.

Estradiol Vaginal Tablets (Vagifem) may affect other vaginally applied treatments.

Get emergency medical help if you have signs of an allergic reaction to Estradiol Vaginal Tablets (Vagifem): hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your healthcare provider right away if you get any of the following warning signs or any other unusual symptoms that concern you:
New breast lumps
Unusual vaginal bleeding
Changes in vision or speech
Sudden new severe headaches
Severe pains in your chest or legs with or without shortness of breath, weakness and fatigue

Common side effects include:
Breast pain
Irregular vaginal bleeding or spotting
Stomach or abdominal cramps, bloating
Nausea and vomiting
Hair loss
Fluid retention
Vaginal yeast infection

If you have used more Estradiol Vaginal tablets (Vagifem) than you should, talk to a doctor or pharmacist. The dose of estradiol is so low that a considerable number of tablets would have to be taken to approach the dose normally used for treatment taken by mouth.

This medicine may be harmful if swallowed. If swallowed or an overdose is suspected, seek emergency medical attention.

If you have any questions about buying discount Estradiol Vaginal Tablets (Vagifem) or any other prescription products online, you can contact us.

Notice: The above information is an educational aid only. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Customer Questions & Answers

If you have questions about this product, fill the form bellow and one of our patient representatives will be happy to answer your questions

    Delivery timetable

    Our average regular delivery time for Vagifem (Estradiol) is 10 days from our Canadian online pharmacy. Delivery times for Vagifem (Estradiol) do vary depending on the location of the dispensary. The reason deliveries take time is primarily due to customs procedures that need to be completed prior to allowing our packages to enter the United States. Expedited and tracked delivery services are available from our Canadian online dispensary. Please speak to one of our online pharmacy service representatives if you have any questions about delivery times for your order

    Related Articles

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    How Vagifem® Helps Relieve Menopausal Symptoms

    Vagifem® is a type of hormone therapy (HT) called local estrogen therapy.  Unlike some other horomone therapies which deliver estrogen to the entire body, this therapy delivers estrogen directly to the uterus and vagina.

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    How to Save Money on Your Prescription Medications

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