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Save Big on Linzess: Affordable Canadian Alternatives

News 2023-08-10 | CanadaOnlineHealth


Linzess (linaclotide) as it is known in the USA is also marketed as Constella in other countries.  It is a prescription drug primarily used to manage irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC). It works by stimulating fluid secretion in the intestines, facilitating regular bowel movements and relieving constipation. The aim of this report is to present an overview of Linzess/Constella, analyze the pricing factors relevant to residents of the United States and Mexico, as well as highlight the availability of cost-effective alternatives in Canada. 

Overview of Linzess/Constella 

Linzess (Linaclotide) was initially approved by the U.S. Food and Drug Administration (FDA) in 2012 for the treatment of adults with IBS-C and CIC. In Mexico, the same medication is marketed as Constella. Linzess/Constella is available in the form of capsules and is typically taken once daily on an empty stomach at least 30 minutes before the first meal of the day. 

Efficiency and Side Effects 

Linzess/Constella has demonstrated effectiveness in alleviating symptoms of IBS-C and CIC in various clinical trials. The symptoms of IBS-C and CIC include bloating, constipation, and abdominal pain. However, the suitability of Linzess varies from person to person, and patients should consult their healthcare providers before making important medical decisions. The most common side effect of Linzess/Constella is diarrhea. Less frequently, mild side effects include flatulence, abdominal pain, bloating, and vomiting.  

Pricing Considerations  

Pricing of prescription medications can vary significantly between countries as of writing this article. In the United States, the cost of Linzess can be high, especially for those without insurance coverage or with high deductibles. The average wholesale price (AWP) of a 30-day supply of Linzess (290 mcg) can range from around $400 to $500. 

In Mexico, where the medication is marketed as Constella, the price can also be relatively high, though generally lower than in the United States. The cost of Constella may depend on factors such as the dosage and the specific pharmacy. It is important for patients in both countries to check with their local pharmacies and explore potential discounts or assistance programs that may be available. 

Canadian Alternatives for US Patients 

Given the high cost of Linzess in the United States, some US patients have explored the option of obtaining the medication from Canada, where prescription drug prices tend to be more affordable. Canadian pharmacies offer several cost-effective alternatives to Linzess, such as generics or similar medications with the same active ingredient, linaclotide. 

However, it is essential to note that purchasing medications from outside the country raises legal and safety concerns. Patients should ensure they are dealing with reputable and licensed Canadian pharmacies that require a valid prescription from a healthcare provider. Additionally, it is advisable to consult with a healthcare professional such as a pharmacist or your physician to ensure the suitability and safety of alternative medications. 

Linzess, although still an expensive medication, is much cheaper when purchased under the name Constella from a Canadian online pharmacy. The price can be as low as just over $200 for a 30-day supply of Constella, which is the Canadian equivalent to Linzess (290 mcg)


Linzess (Constella) is a widely used medication for the treatment of IBS-C and CIC. However, the high cost of Linzess in the United States and Mexico can pose financial challenges for patients. Exploring cost-effective alternatives available in Canada may be an option for US patients, but it is crucial to consider legal and safety aspects when purchasing medications from abroad. Patients should consult their healthcare providers and explore local resources, assistance programs, or potential discounts to help manage the cost of Linzess/Constella in their respective countries. 

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